The cold chain is the part of the supply chain where a mistake is measured in degrees and hours and the product cannot be recovered: a pallet of frozen shrimp that thaws, a truckload of lettuce held too warm, or a shipment of vaccine that leaves its 2–8°C band is a write-off, and sometimes a safety recall. It is also the most capital- and energy-intensive part of warehousing. Temperature-controlled warehouses cost far more to build and run than ambient ones, and two listed US REITs dominate public ownership: Lineage, which listed on Nasdaq in Jul 2024 in the year's largest IPO (~$4.4bn raised at $78 a share, reported) and traded at ~$36 at the end of Oct 2026 (third-party quote, less than half the IPO price), and Americold. Pharma logistics is a higher-margin specialty that integrators and forwarders are buying into: UPS closed its acquisition of Andlauer Healthcare Group on 1 Nov 2025 (C$55.00 a share in cash, ~C$2.2bn, ~US$1.6bn). Rules are tightening and loosening at once. The FDA's food-traceability rule under FSMA section 204 was due on 20 Jan 2026; its compliance date moved to 20 Jul 2028, and Congress directed the FDA not to enforce it before then. Section 232 tariffs on patented pharmaceuticals and their active ingredients — up to 100%, from 31 Jul 2026 for 17 named companies and 29 Sep 2026 for other importers, 15% for the EU, Japan, Korea, Switzerland and Liechtenstein, with generics and biosimilars excluded for now — push drug makers towards US production and change what flows through pharma networks. This section explains temperature bands and units, cold-storage economics, reefer shipping and trucking, pharma logistics, COVID vaccine distribution (2020–21), food distribution and safety rules, the energy and labour exposure, and how to read the companies.
What the study covers
- 1Overview: logistics with a thermometer
- 2Units and temperature bands
- 3Temperature-controlled warehousing
- 4Reefer shipping, ports and air
- 5Reefer trucking and food distribution
- 6Pharma logistics
- 7COVID vaccine distribution, 2020–21
- 8Food safety and traceability
- 9Labour, energy and climate exposure
- 10How to read cold-chain numbers
- 11Key numbers
- 12Landmark companies and cases
- 13Pitfalls
- 14How an expert thinks about it
- 15Glossary
Companies in this study
- Lineage
- Sysco
- UPS
- FedEx
- DHL Group
- Kuehne+Nagel
- A.P. Moller-Maersk
- CMA CGM
- Mediterranean Shipping Company
- Prologis
- Walmart
- Costco
- Amazon Logistics
- Ocado
- Tesco
- C.H. Robinson
- Ryder System
- Getir. Drug wholesalers and pharma companies are profiled in the Healthcare knowledge base: McKesson, Cencora, Cardinal Health, Pfizer, Amazon Health, Walmart Health; see Healthcare 06 Pharmacy, Drug Distribution and PBMs and Healthcare 05 Pharmaceuticals. Refrigeration power costs link to Energy 05 Power Markets.